Evaluation Of Systemic Omega-3 PUFAs On Orthodontic Tooth Movement In A Rabbit Model: Randomized Clinical Trial

Document Type : Original Article

Authors

1 Lecturer of orthodontics, Faculty of dentistry, KafrelSheikh univeristy

2 Biology department, Faculty of dentistry, Alexandria University

Abstract

Objective: is to evaluate the effect of systemic administration of Omega-3 fatty acids on orthodontic tooth movement (OTM) with histological analysis. Materials and Methods: OTM was induced in 20 adult albino New Zealand rabbits with NiTi coil spring for 21 days. Omega-3 or Saline was given every day via oral gavage during experimental period. Animals were sacrificed for histomorphometric analysis of alveolar bone remodeling after 21 days of OTM. Results: A significant difference in OTM amount was found in the 3rd week of OTM with means (1.445 ± 0.13), (1.72 ± 0.15) for experimental and control groups, respectively. Histomorphometric analysis showed a significant reduction in the area of active bone-resorptive lacunae and a significant decrease in osteoclastic activity related to omega-3 group after 3 weeks. A significant difference in osteoclast count is found, omega-3 group about (0.21 ± 0.09) while control group about (0.33 ± 0.11). Conclusions: A strong evidence of the osteoclastic inhibitory effect of systemic Omega-3 had been found which decreased percentage and amount of OTM.

Keywords

Egyptian Orthodontic Journal
Volume 62, Issue 1
December 2022
Pages 117-128

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