0.05). The histological findings showed no difference in the number and activity of osteoclasts in the pressure sides in both control and Imuran subgroups after one day (P < 0.05). On the other hand, the number and actvity of osteoclasts were significantly higher (P > 0.05) in the control subgroups than the study subgroups after one and two weeks. Finally, it could be concluded that; Azathioprine (Imuran) significantly retards the orthodontic tooth movement and decreases the number and activity of osteoclasts.]]>
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